Fig. 11From: Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?Schematic representation of TLR4 signaling cascades. Signal transduction of TLR4 through the activation of MyD88/TIRAP and TRAM/TRIF pathways, leads to potentiate the innate immune responses and inhibit signal transduction of insulin, primarily through serine phosphorylation of IRS. Adopted from Kim and Sears 2010Back to article page