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Fig. 13 | Journal of Biomedical Science

Fig. 13

From: Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?

Fig. 13

Mechanism of hyperglycemia- and dyslipidemia-induced inflammation for the development of IR and T2DM. Hyperglycemia and dyslipidemia collectively provoke the activation of pro-inflammatory mediators through the involvement of several metabolic pathways. Once, these pro-inflammatory mediators are released, they induce tissue-specific inflammation due to which IR in peripheral tissues and impaired insulin secretion in pancreatic islets occur that ultimately lead to overt T2DM. Adapted from Akash et al. [30]

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Journal of Biomedical Science

ISSN: 1423-0127