Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

Table 1 ALDH2 Polymorphism (rs671) in AF Patients and Controls

	Genotype distribution			HW-test	allelic model (G vs A)			dominant model (GG + GA vs AA)		recessive model (GG vs GA + AA)
	GG	GA	AA	P	A allele frequency	P	OR(95%CI)	P	OR(95%CI)	P	OR(95%CI)
AF	380	176	20	0.95	0.19	7.6x10⁻⁴	0.6 (0.4–0.8)	0.1	0.7 (0.4–1.1)	0.8x10⁻³	0.7 (0.6–0.9)
AF	(66.0%)	(30.6%)	(3.5%)	0.95	0.19
Control	1126	710	99	0.34	0.24
Control	(58.2%)	(36.7%)	(5.1%)	0.34	0.24

The results were tested by the chi-square test and the Cochran–Armitage trend test
The G allele was considered as the reference allele in the allelic model. The A allele was dysfunctional allele
The dysfunctional allele A of ALDH2 SNP rs671 significantly decreased in AF patients (OR 0.6, P = 7.0x10-4)
OR odds ratio

ISSN: 1423-0127