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Table 2 Characteristics of AF Patients and ALDH2 Genotype

From: Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

rs671 (Risk Allele = A)

G/G

G/A

A/A

P

No. of patients

380

176

20

Clinical Characteristics

 Age (year)

62 ± 11

61 ± 10

62 ± 12

0.698

 Male gender

275 (72.4%)

138 (78.4%)

14 (70%)

0.377

 BMI (kg/m2)

24.1 ± 3.4

24.2 ± 3.3

25.3 ± 3.8

0.380

 PAF

232 (61.0%)

91 (51.7%)

11 (55.0%)

0.083

 Hypertension

230 (60.6%)

79 (44.9%)

10 (50%)

0.109

 Diabetes mellitus

68 (17.8%)

22 (12.5%)

2 (10.0%)

0.266

 Ischemic heart disease

7 (1.8%)

12 (6.8%)

2 (10.0%)

0.290

 AHI/hour

20.5 ± 13.5

18.9 ± 13.5

17.0 ± 11.4

0.430

Echocardiographic Findings

 LAD (mm)

39.2 ± 6.4

39.8 ± 6.4

38.1 ± 4.6

0.641

 LA volume index (ml/m2)

42.1 ± 13.4

41.5 ± 11.6

38.9 ± 7.1

0.338

 IVSTd (mm)

0.89 ± 0.18

0.89 ± 0.16

0.95 ± 0.15

0.545

 LVDd (mm)

48.2 ± 4.9

48.1 ± 5.5

46.9 ± 3.9

0.463

 EF (%)

60.0 ± 7.3

59.0 ± 6.3

60.0 ± 5.5

0.466

EPS parameters

 AA (mm)

844.8 ± 176.7

867.3 ± 159.9

822.8 ± 148.4

0.465

 AH (ms)

95.1 ± 24.0

94.7 ± 26.7

86.5 ± 28.7

0.371

 HV (ms)

42.8 ± 24.1

42.0 ± 11.5

39.2 ± 8.4

0.513

 AVN ERP (ms)

301.8 ± 73.8

317.9 ± 93.3

304.3 ± 50.3

0.123

 A ERP (ms)

229.6 ± 36.7

237.8 ± 51.2

207.5 ± 37.6

0.796

 SNRT (ms)

1362.6 ± 405.4

1383.7 ± 312.1

1312.2 ± 287.4

0.901

  1. Binary variables were compared by χ2 test under the allelic model, and quantitative traits were tested for association by linear regression. Data was mean ± SD
  2. BMI body mass index, PAF paroxysmal atrial fibrillation, AHI Apnea Hypopnea Index, LAD left atrial diameter, IVSTd interventricular septal thickness at end-diastole, LVDd LV Dimension diastolic diameter, EF ejection fraction, AVN atrioventricular node, A atrium, SNRT sinus node recovery time