Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

Table 3 ALDH2 Polymorphism (rs671) in Lone AF Patients and Control II

	Genotype distribution			HW-test	allelic model (G vs A)			dominant model (GG + GA vs AA)		recessive model (GG vs GA + AA)
	GG	GA	AA	P	A allele frequency	P	OR(95%CI)	P	OR(95%CI)	P	OR(95%CI)
Lone AF	123	54	5	0.74	0.18	1.3x10⁻²	0.7 (0.5–0.9)	0.43	0.7 (0.3–1.8)	0.7x10⁻²	0.6 (0.5–0.9)
Lone AF	(67.6%)	(29.7%)	(2.7%)	0.74	0.18
Control II	520	358	36	0.01	0.24
Control II	(56.9%)	(39.2%)	(3.9%)	0.01	0.24

Control II means control without hypertension or organic heart diseases
The results were tested by the chi-square test and the Cochran–Armitage trend test
The G allele was considered as the reference allele in the allelic model. The A allele was dysfunctional allele
The dysfunctional allele A of ALDH2 SNP rs671 significantly decreased in Lone AF patients (OR 0.7, P = 0.01)
OR odds ratio