Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

Table 4 ADH1B Polymorphism (rs1229984) in Lone AF Patients and Control II

	Genotype distribution			HW-test	allelic model (G vs A)			dominant model (GG + GA vs AA)		recessive model (GG vs GA + AA)
	GG	GA	AA	P	G allele frequency	P	OR(95%CI)	P	OR(95%CI)	P	OR(95%CI)
Lone AF	12	80	90	0.30	0.29	7.0x10⁻³	1.4 (1.1–1.8)	0.005	1.6 (1.1–2.2)	0.28	1.4 (0.7–2.7)
Lone AF	(6.6%)	(44.0%)	(49.5%)	0.30	0.29
Control II	43	317	554	0.78	0.22
Control II	(4.7%)	(34.7%)	(60.6%)	0.78	0.22

The results were tested by the chi-square test and the Cochran–Armitage trend test
The A allele was considered as the reference allele in the allelic model. The G allele was the dysfunctional allele
The dysfunctional allele G of ADH1B SNP rs1229984 significantly increased in lone AF patients (OR 1.4, P = 7.0x10-4)
OR odds ratio

ISSN: 1423-0127