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Table 5 Characteristics of Lone AF Patients and ADH1B Genotype

From: Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

rs1229984 (Dysfunctional Allele = G)

G/G

A/G

A/A

P

No. of patients

12

80

90

Clinical Characteristics

 Age (year)

61 ± 11

61 ± 10

61 ± 11

0.959

 Age of onset (year)

58 ± 11

56 ± 12

57 ± 11

0.780

 Male gender

10 (83.3%)

66 (82.5%)

79 (87.8%)

0.827

 BMI (kg/m2)

23.7 ± 2.7

24.3 ± 3.3

23.9 ± 3.4

0.775

 PAF

8 (66.7%)

45 (56.3%)

55 (61.1%)

0.857

 Diabetes mellitus

0 (0%)

16 (20.0%)

15 (16.7%)

0.091

 Ischemic heart disease

0 (0%)

1 (1.2%)

0 (0%)

0.898

 AHI/hour

19.1 ± 11.9

15.7 ± 15.0

18.8 ± 14.5

0.389

 Alcohol intake (ethanol g/day)

45.1 ± 33.5

27.8 ± 27.6

22.7 ± 24.3

0.057

Echocardiographic Findings

 LAD(mm)

34.2 ± 10.8

37.1 ± 6.4

37.4 ± 5.5

0.262

 LA volume index (ml/m2)

37.8 ± 6.1

37.8 ± 11.7

39.4 ± 9.6

0.346

 IVSTd (mm)

0.90 ± 0.12

0.83 ± 0.14

0.89 ± 0.14

0.134

 LVDd (mm)

51.7 ± 4.8

46.9 ± 3.9

48.5 ± 5.4

0.525

 EF(%)

61.6 ± 5.8

59.3 ± 5.7

58.0 ± 7.6

0.109

EPS parameters

 AA (mm)

861.3 ± 207.3

829.2 ± 152.8

831.3 ± 147.8

0.600

 AH (ms)

114.5 ± 9.2

91.7 ± 3.1

93.1 ± 2.3

0.316

 HV (ms)

45.6 ± 9.5

39.6 ± 8.5

40.5 ± 8.8

0.693

 AVN ERP (ms)

289 ± 64

151 ± 24

155 ± 28

0.117

 A ERP (ms)

290.0 ± 40.0

238 ± 38.9

234 ± 29.8

0.0453*

 SNRT (ms)

1553.2 ± 622.6

1382.2 ± 448.6

1390.9 ± 326.1

0.643

  1. Binary variables were compared by χ2 test under the allelic model, and quantitative traits were tested for association by linear regression. Data was means, *P < 0.05 by liner regression test
  2. BMI body mass index, PAF paroxysmal atrial fibrillation, AHI Apnea Hypopnea Index, LAD left atrial diameter, IVSTd interventricular septal thickness at end-diastole, LVDd LV Dimension diastolic diameter, EF ejection fraction, AVN atrioventricular node, A right atrium, SNRT sinus node recovery time, ERP effective refractory period