Fig. 5
From: The paradox role of caspase cascade in ionizing radiation therapy
A schematic representation of the role of COX-2 (Cyclooxigenases-2) in proliferation of cancer cells. Radiation as well as PGE2 (Prostaglandin E2) are able to transactivate EGFR (Epidermal Growth Factor Receptor) that upregulates the level of pro- survival protein through PI3K/AKT, MAPK/ERK and JAK/STAT pathways. Also, caspase activation leads to release of arachidonic acid