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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma

Fig. 4

Kaplan–Meier univariate survival analysis of DACT1 / DACT2 expression and methylation status in ESCC. a, b, c Kaplan–Meier curves for cumulative survival stratified by DACT1 and DACT2 expression: showing a direct correlation between DACT1 or DACT2 expression and ESCC patient’s survival. d, e, f, g Kaplan–Meier curves for cumulative survival stratified by the methylation status of two regions of DACT1 and one region of DACT2: There was not correlation between the region 1 methylation status of DACT1 and the ESCC patient’s survival. The hypermethylation of TSS-region in DACT1 and DACT2 were associated with the poor patient survival of ESCC cases; Simultaneous methylation of DACT1 and DACT2 showed worst prognosis. (H) Kaplan–Meier curves for cumulative survival stratified by methylation status and UGIC family history: ESCC patients with positive UGIC family history and DACT1 or DACT2 methylation showed poor patient survival. (I) Kaplan–Meier curves for cumulative survival stratified by methylation status and TNM stages: Stage III and IV ESCC patients with DACT1 or DACT2 methylation showed the poor patient survival

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Journal of Biomedical Science

ISSN: 1423-0127