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Table 1 Altered cardiac metabolism in diabetes

From: PPARs modulate cardiac metabolism and mitochondrial function in diabetes

Alteration of cardiac metabolism Mechanism
Changes in fuel preference [1921] Increases fatty acid β-oxidation
Decreases glucose oxidation
Defect in glucose utilization [19, 20, 22] Reduces GLUT4 expression and translocation
High fatty acid oxidation suppresses PFK1 through accumulation of citrate in the cytosol
High fatty acid oxidation inhibits PDH through activation of PDK
Alterations in fatty acid utilization [13, 14, 19, 20] Increases the expression of fatty acid transporters
PPAR-α activation promotes the expressions of genes that regulate fatty acid β-oxidation
  1. GLUT4, glucose transporter type 4; PFK1, phosphofructokinase 1; PDH, pyruvate dehydrogenase; PDK, pyruvate dehydrogenase kinase