Fig. 1
From: Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
Structure of ALDH2 enzyme. a ALDH2 monomer displaying the three phosphorylation sites identified by LC-MS-MS: Thr185, Ser279, and Thr412 (blue). Also highlighted are the catalytic Cys302 (green) and the site of the ALDH2*2 or Asian mutation: Glu487 (red). b Tetramer of an active ALDH2 enzyme form. Thr185, Ser279 and Thr412 are marked in subunits A as in (a). The distance of between the two Ser279s on subunits A and D is also indicated