Fig. 5
From: Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
Alignment of amino acid sequences of the 18 human ALDH isozymes. Amino acid sequences of 18 human ALDH isozymes were aligned based on their sequence homology. For longer ALDH isozymes, both N- and C-terminal sequences were truncated to obtain the best fitted alignment against the ALDH2 protein sequence from its amino acid residues 76 to 500 as marked (without the 17 a.a. N-terminal mitochondria targeting sequence). Serine and threonine at positions T187, S279, T384, T412, T433 and S471 the conserved are denoted in red letters. The negatively charged amino acids, D and E, are in blue. The conserved catalytic site, Cysteine 302 (C302) residues, are marked in green. For GenBank accession numbers of all ALDH isozymes, see Methods