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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials

Fig. 2

Effects of sarcosine and DMG alone or combined with glutamate on excitatory field potentials. The effects of glutamate (100 μM), glycine (10 μM), and glutamate plus glycine were examined prior to the glycine methyl derivatives to verify the slice activity. The experimental protocol (a), the representative field potential recordings (b), and the frequency and amplitude of NMDA receptor-mediated excitatory field potentials after perfusion with sarcosine or DMG (100 μM) alone and various concentrations of sarcosine (c) or DMG (d) (10, 30, and 100 μM) plus glutamate (100 μM). (Frequency: sarcosine F7,21 = 29.43, p < 0.001; DMG F7,21 = 48.94, p < 0.001; Amplitude: sarcosine F7,21 = 28.17, p < 0.001; DMG F7,21 = 5.28, p < 0.001). Data are expressed as percentage of baseline, mean ± SEM (n = 4). ***p < 0.001 compared with baseline

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