Fig. 2

Linopirdine reduces resuscitation fluid requirements after hemorrhagic shock. Animals were hemorrhaged to a mean arterial blood pressure (MAP) of 25 mmHg for 30 min, followed by fluid resuscitation to a MAP of 70 mmHg. At the end of the shock period (t = 30 min), vehicle (n = 4, open squares), 1 mg/kg (n = 5, light grey squares), 3 mg/kg (n = 3, black squares) or 6 mg/kg (n = 3, open circles) linopirdine in 0.5 mL normal saline were injected intravenously. Arrows indicate the time point of drug injection. *: p < 0.05 vs. vehicle. a. Mean arterial blood pressure (MAP, mmHg). b. Hemorrhage volume in % of total blood volume (%BV hemorrhage). c. Resuscitation fluid requirements (mL/kg) to maintain MAP at 70 mmHg