Fig. 4

Supplementation of resuscitation fluids with linopirdine reduces resuscitation fluid requirements after hemorrhagic shock. Animals were hemorrhaged to a mean arterial blood pressure (MAP) of 25 mmHg for 30 min, followed by fluid resuscitation to a MAP of 70 mmHg. At the end of the shock period (t = 30 min), animals were resuscitated with normal saline (NS, vehicle, n = 4, open circles) or NS supplemented with 1.25 (n = 4,open squares), 6.25 (n = 3, light grey squares), 12.5 (n = 3, dark grey squares) or 200 μg/mL (n = 6, black squares) linopirdine. Arrows indicate the time point of drug injection. *: p < 0.05 vs. vehicle. a. Mean arterial blood pressure (MAP, mmHg). b. Hemorrhage volume in % of total blood volume (%BV hemorrhage). c. Resuscitation fluid requirements (mL/kg) to maintain MAP at 70 mmHg