Fig. 1

Localization of JAB1 in CD68⁺ MΦ in atherosclerotic plaques of hypercholesterolemic ApoE^−/− mice. Representative cross-sections of the brachiocephalic trunk of ApoE^−/− mice at 30 weeks of age are shown. In an atherosclerotic plaque of ApoE^−/− mice JAB1-immunoreactivity (a, b) was localized in CD68⁺ MΦ (c, d), as seen in merge (e, f) labelled by *. JAB1- and CD68-immunoreactivity was detected by confocal laser scanning microscopy (Nikon Eclipse) and analyzed with Fiji ImageJ software. Nuclei were counterstained with DAPI (blue). Representative photos from 4 independent experiments are shown. Bars: 50 μm