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Table 2 Brain metabolite concentrations obtained in fast MRSI techniques

From: Fast magnetic resonance spectroscopic imaging techniques in human brain- applications in multiple sclerosis

Methods TE/TR (ms) Metabolite (mM) Tacq (min) Brain region/ FOV/ voxel size/ Cohort/ Bo (Tesla) Ref
EPSI 18/1550 GM in frontal lobe left: NAA:11.10 ± 0.32, tCho:2.04 ± 0.16, Glx:10.22 ± 0.53
WM in frontal lobe left: NAA:9.51 ± 0.27, tCho:1.95 ± 0.16, Glx:6.43 ± 0.34
16 whole brain/ 28 × 28 × 18 cm3/1 cm3/ 20 HCs/ 3 T [82]
EPSI with OVS 15/2000 GM: NAA:8.6 ± 0.7, Glu:12.8 ± 1.5, tCho:1.4 ± 0.2.
WM: NAA:7.2 ± 0.7, Glu:7.0 ± 1.1, tCho:1.4 ± 0.2
8.5 WM and GM/ 26 cm/ 1 cm3/ 9 HCs/ 3 T [53]
3D
GRAPPA-EPSI
70/1710 aNAA: 595 ± 37.9, Cr: 346 ± 23.9
Cho: 100 ± 9.7
16 Whole brain/ 28 × 28 × 18 cm3/ 0.31 cm3/ 25 patients with mild traumatic brain injuries (mTBI) & 25 HCs/ 3 T [84]
GRAPPA-EPSI 15/2000 GM: NAA:15.36 ± 2.62, Glx:18.40 ± 3.19, Cho:3.19 ± 0.58
WM: NAA: 14.46 ± 1.79, Glx: 11.01 ± 3.20, Cho:3.19 ± 0.45
1.5 WM and GM/ 24 cm/ 0.85 cm3/ 5 HCs/ 3 T [89]
3D SENSE-EPSI 15/2000 NAA:9.5 ± 4.3, Cho:1.4 ± 0.9, Glu:8.8 ± 5.2, Cr:7.2 ± 2.8 8.5 WM and GM/ 24 × 24 × 10 cm/ 0.7 cm3/ HCs/ 3 T [49]
3D EPSI-MRSI 70/1710 bGM: NAA:4948 ± 75, Cr: 3461 ± 53,
Cho: 544 ± 13 in Occipital
WM: NAA:5165 ± 81, Cr: 3048 ± 48,
Cho: 671 ± 12 in Occipital
NA WM and GM/ 28 × 28 × 18 cm3/ 0.31 cm3/ 88 HCs/ 3 T [79]
3D PRESS-MRSI 144/1500 Concentration for age groups (25–32)
NAA/Cr:1.8 in Frontal lobe
NAA/Cr : 1.9 in Occipital lobe
13 Whole brain/ 32 cm /1 cm3/ 8 HCs/ 1.5 T [61]
  1. aMean metabolite concentrations averaged over all voxels of WM brain tissue in parietal lobe
  2. bAverage metabolite values in IU