Skip to main content

Table 3 Brain metabolite concentration were acquired for MS patients and HCs by applying PRESS-MRSI and fast MRSI methods

From: Fast magnetic resonance spectroscopic imaging techniques in human brain- applications in multiple sclerosis

Methods

TE/TR (ms)

Metabolite (mM)

Tacq a (min)

Brain region/ FOV/voxel size/Cohort/Bo (Tesla)

Ref

2D-MRSI

30/3000

CGM:

Controls, tNAA: 8.3 ± 1.0, Cr: 5.9 ± 0.8

RRMS, tNAA: ↓, Cr: ↓

29

NAWM, CGM/ 30 cm/2.34 mL/ 16 RRMS, 12 HCs/1.5 T

[111]

2D-MRSI

135/1800

Controls, NAA/Cr: 2.22 ± 0.19

RRMS, NAA/Cr: ↓

PPMS, NAA/Cr: ↓

13

WM, NAWM/ 21 × 21 cm/ 2.4 cm3/ 15 PPMS, 13 RRMS & 20 HCs/ 1.5 T.

[104]

PRESS-MRSI

30/3000

NAWM:

Controls, tNAA: 8.82, Cr: 4.87

RRMS, tNAA: ↓, Cr : ↓

 

NAWM, CGM/ 30x30 cm/ 2.3 mL/ 25 RRMS, 28 HCs/ 1.5 T

[105]

2D-MRSI

135/1500

GM:

Controls, NAA:10.63 ± 0.6, Cr:6.13 ± 0.31 PPMS, NAA: ↓, Cr: ↓

WM:

Controls, NAA:11.48 ± 0.37, Cr: 5.35 ± 0.45

PPMS, NAA: ↓, Cr: ↓

7

WM and GM/ 16 ×16 cm2/ 2 cm3/ 4 PPMS & 4 HCs/ 1.5 T

[112]

PRESS-MRSI

30/3000

NAWM: Controls, tNAA: 9.18 ± 0.6

RRMS, tNAA: ↓

CGM: Controls, tNAA: 9.28 ± 1.02

RRMS, tNAA: ↓

NA

NWWM and CGM/ 30x30 cm/ 20 RRMS, 10 HCs /1.5 T

[107]

3D-MRSI

70/1710

GM: Controls, NAA:8.5 ± 0.6, Cr: 6.8 ± 0.6

RRMS, NAA: ↑, Cr: ↑

WM: Controls, NAA:7.9 ± 0.6, Cr: 4.9 ± 0.2

RRMS, NAA: ↓, Cr: ↑

34

WM and GM/ 16x16 cm/ 0.75 cm3, 18 RRMS, 10 HCs/ 3 T

[102]

MRSI

135/1000

RRMS, NAA: 8.45 ± 0.88, Cr: 5.2 ± 0.73

PPMS, NAA: ↓, Cr:↑

45

MS lesion for RRMS & PPMS/ 16×16/ 1.2 cm3/ 15 RRMS, 15 PPMS/ 3 T

[113]

2D PRESS-MRSI

135/1500

NAWM:

Controls, NAA: 12.3 ± 0.4, Cr: 8.4 ± 0.4

RRMS, NAA: ↑, Cr: ↑

SPMS, NAA: ↓, Cr: ↓

15

Fronto-parietal WM/ 16x16 cm/1 cm3/ 27 RRMS, 10 SPMS & 8 HCs/ 3 T

[109]

EPSI

272/4000

Normal VEP, NAA: 7692 ± 632

Abnormal VEP NAA: ↓

9

Mid-thalamus / 24 cm/ 9 MS with abnormal VEP& 8 MS normal VEP/ 1.5 T

[5]

3D-EPSI

144/2000

Central brain:

Controls, NAA/Cr: 1.963 ± 0.167

MS patients, NAA/Cr: ↓

20

Corpus callosum, STB/ 24x24x16 cm/ 1 cm3/ 9 RRMS, 21 SPMS, 18 PPMS & 10 HCs/ 1.5 T

[114]

EPSI

144/4300

NAA/Cr: 1.55 ± 0.1 from RRMS

20

Whole brain/ not reported /1 cm3, 20 RRMS & 75 HCs/ 1.5 T

[115]

Spiral-MRSI

144/2000

WM:

Controls, NAA: 159 A.U. (mean conc.)

RRMS, NAA: ↓ SPMS, NAA: ↓

15

NAWM, GM in supratentorial brain/ 24 cm/ 1.2 mL/ 5 RRMS, 5 SPMS & 9 HCs/ 1.5 T

[4]

EPSI

144/4300

Controls, NAA/Cr: 1.5 ± 0.09

MS patients, NAA/Cr: ↑

20

Whole brain/ not reported/ 1 cm3, 18 RRMS & 18 HCs/ 1.5 T

[86]

3D-EPSI

20/1720

GM:

Controls, NAA: 10 ± 0.85, Glx: 6.5 ± 1.1

MS patients, NAA: ↓, Glx: ↓

17.48

Whole brain/ 28×28×18 cm/ 1 cm3, 19 RRMS & 19 HCs / 3 T

[117]

  1. a Tacq acquisition time