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Table 3 Brain metabolite concentration were acquired for MS patients and HCs by applying PRESS-MRSI and fast MRSI methods

From: Fast magnetic resonance spectroscopic imaging techniques in human brain- applications in multiple sclerosis

Methods TE/TR (ms) Metabolite (mM) Tacq a (min) Brain region/ FOV/voxel size/Cohort/Bo (Tesla) Ref
2D-MRSI 30/3000 CGM:
Controls, tNAA: 8.3 ± 1.0, Cr: 5.9 ± 0.8
RRMS, tNAA: ↓, Cr: ↓
29 NAWM, CGM/ 30 cm/2.34 mL/ 16 RRMS, 12 HCs/1.5 T [111]
2D-MRSI 135/1800 Controls, NAA/Cr: 2.22 ± 0.19
RRMS, NAA/Cr: ↓
PPMS, NAA/Cr: ↓
13 WM, NAWM/ 21 × 21 cm/ 2.4 cm3/ 15 PPMS, 13 RRMS & 20 HCs/ 1.5 T. [104]
PRESS-MRSI 30/3000 NAWM:
Controls, tNAA: 8.82, Cr: 4.87
RRMS, tNAA: ↓, Cr : ↓
  NAWM, CGM/ 30x30 cm/ 2.3 mL/ 25 RRMS, 28 HCs/ 1.5 T [105]
2D-MRSI 135/1500 GM:
Controls, NAA:10.63 ± 0.6, Cr:6.13 ± 0.31 PPMS, NAA: ↓, Cr: ↓
WM:
Controls, NAA:11.48 ± 0.37, Cr: 5.35 ± 0.45
PPMS, NAA: ↓, Cr: ↓
7 WM and GM/ 16 ×16 cm2/ 2 cm3/ 4 PPMS & 4 HCs/ 1.5 T [112]
PRESS-MRSI 30/3000 NAWM: Controls, tNAA: 9.18 ± 0.6
RRMS, tNAA: ↓
CGM: Controls, tNAA: 9.28 ± 1.02
RRMS, tNAA: ↓
NA NWWM and CGM/ 30x30 cm/ 20 RRMS, 10 HCs /1.5 T [107]
3D-MRSI 70/1710 GM: Controls, NAA:8.5 ± 0.6, Cr: 6.8 ± 0.6
RRMS, NAA: ↑, Cr: ↑
WM: Controls, NAA:7.9 ± 0.6, Cr: 4.9 ± 0.2
RRMS, NAA: ↓, Cr: ↑
34 WM and GM/ 16x16 cm/ 0.75 cm3, 18 RRMS, 10 HCs/ 3 T [102]
MRSI 135/1000 RRMS, NAA: 8.45 ± 0.88, Cr: 5.2 ± 0.73
PPMS, NAA: ↓, Cr:↑
45 MS lesion for RRMS & PPMS/ 16×16/ 1.2 cm3/ 15 RRMS, 15 PPMS/ 3 T [113]
2D PRESS-MRSI 135/1500 NAWM:
Controls, NAA: 12.3 ± 0.4, Cr: 8.4 ± 0.4
RRMS, NAA: ↑, Cr: ↑
SPMS, NAA: ↓, Cr: ↓
15 Fronto-parietal WM/ 16x16 cm/1 cm3/ 27 RRMS, 10 SPMS & 8 HCs/ 3 T [109]
EPSI 272/4000 Normal VEP, NAA: 7692 ± 632
Abnormal VEP NAA: ↓
9 Mid-thalamus / 24 cm/ 9 MS with abnormal VEP& 8 MS normal VEP/ 1.5 T [5]
3D-EPSI 144/2000 Central brain:
Controls, NAA/Cr: 1.963 ± 0.167
MS patients, NAA/Cr: ↓
20 Corpus callosum, STB/ 24x24x16 cm/ 1 cm3/ 9 RRMS, 21 SPMS, 18 PPMS & 10 HCs/ 1.5 T [114]
EPSI 144/4300 NAA/Cr: 1.55 ± 0.1 from RRMS 20 Whole brain/ not reported /1 cm3, 20 RRMS & 75 HCs/ 1.5 T [115]
Spiral-MRSI 144/2000 WM:
Controls, NAA: 159 A.U. (mean conc.)
RRMS, NAA: ↓ SPMS, NAA: ↓
15 NAWM, GM in supratentorial brain/ 24 cm/ 1.2 mL/ 5 RRMS, 5 SPMS & 9 HCs/ 1.5 T [4]
EPSI 144/4300 Controls, NAA/Cr: 1.5 ± 0.09
MS patients, NAA/Cr: ↑
20 Whole brain/ not reported/ 1 cm3, 18 RRMS & 18 HCs/ 1.5 T [86]
3D-EPSI 20/1720 GM:
Controls, NAA: 10 ± 0.85, Glx: 6.5 ± 1.1
MS patients, NAA: ↓, Glx: ↓
17.48 Whole brain/ 28×28×18 cm/ 1 cm3, 19 RRMS & 19 HCs / 3 T [117]
  1. a Tacq acquisition time