Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

Nguyen, Phan Nguyen Nhi; Huang, Chiu-Jung; Sugii, Shigeki; Cheong, Soon Keng; Choo, Kong Bung

doi:10.1186/s12929-017-0326-z

Journal of Biomedical Science

Table 1 Expression of C19MC and the miR-372 family miRNAs in stem cells

From: Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

miRNA^a	Gene copy	Expression^b			Log₂(fold change)
miRNA^a	Gene copy	HWP	MSC	iPSC	Log₂(fold change)
miR-512-5p	2	-	+/-	+	5.265 ± 0.58**
miR-512-3p		+	+	+	3.600 ± 1.85*
miR-1323 (5p)	1	-	-	+	7.319 ± 0.50**
miR-498 (5p)	1	+	+	+	3.857 ± 0.99**
miR-520e (3p)	1	-	-	+	4.001 ± 0.20**
miR-515-5p	2	-	-	+	7.053 ± 0.63**
miR-515-3p		-	-	+	4.083 ± 0.45**
miR-519e-5p	1	-	-	+	3.046 ± 0.55**
miR-519e-3p		-	-	+	3.320 ± 0.44**
miR-520f-3p	1	-	-	+	6.275 ± 0.75**
miR-519c-3p	1	-	-	+	5.685 ± 0.66**
miR-1283 (5p)	2	-	-	+	3.055 ± 0.29**
miR-520a-5p	1	-	-	+	4.863 ± 0.71**
miR-520a-3p		+	+	+	0.869 ± 1.48
miR-526b-5p	1	-	+	+	4.233 ± 0.13*
miR-526b-3p		-	+/-	+	6.906 ± 0.81**
miR-519b-3p	1	-	+	+	2.620 ± 1.36*
miR-518f-5p	1	-	+/-	+	3.901 ± 0.50**
miR-518f-3p		-	+/-	+	6.971 ± 0.59**
miR-520b (3p)	1	-	-	+	8.375 ± 0.54**
miR-518b (3p)	1	+	+	+	3.706 ± 0.98*
miR-526a (5p)	2	-	+	+	2.741 ± 1.95
miR-520c-3p	1	-	-	+	8.285 ± 0.70**
miR-518c-5p	1	n.d.	-	+	4.135 ± 0.34
miR-518c-3p		-	-	+	6.282 ± 0.76**
miR-524-5p	1	-	-	+	3.810 ± 0.60**
miR-524-3p		-	-	+	4.202 ± 0.63**
miR-517a-5p	1	-	+/-	+	2.328 ± 0.65*
miR-517a-3p		-	-	+	8.262 ± 0.62**
miR-519d-3p	1	-	+/-	+	4.819 ± 2.56*
miR-521 (3p)	2	+	+	+	1.500 ± 0.30*
miR-520d-5p	1	-	-	+	3.933 ± 0.34**
miR-520d-3p		n.d.	+	+	0.233 ± 3.93
miR-517b-3p	1	-	+/-	+	6.474 ± 0.73**
miR-520g-3p	1	+	+	+	6.014 ± 1.27**
miR-516b-5p	2	-	-	+	3.243 ± 0.52
miR-518e-5p	1	-	+	+	3.344 ± 1.88
miR-518e-3p		+	+	+	1.386 ± 0.49*
miR-518a-3p	2	+	+	+	2.013 ± 1.04*
miR-518d-3p	1	-	-	+	3.613 ± 0.47**
miR-520h (3p)	1	-	+	+	5.618 ± 0.82**
miR-522-3p	1	-	-	+	4.060 ± 0.47**
miR-519a-3p	2	-	-	+	6.586 ± 0.56**
miR-516a-5p	2	-	-	+	3.583 ± 0.32**
miR-516a-3p		-	+/-	+	0.758 ± 0.52*
miR-371a-5p	1	-	-	+	6.256 ± 1.14**
miR-372a-3p		+	+/-	+	1.094 ± 5.34
miR-372-3p	1	+	+	+	7.201 ± 0.11**
miR-373-5p	1	-	-	+	2.500 ± 1.27*
miR-373-3p		-	-	+	7.240 ± 1.39**

^amiRNA-5p and -3p designations are based on miRBase ver. 21; -5p and -3p designations in brackets are not annotated in miRBase, but are the presumptive precursor arms derived from sequence alignment. miRNAs are arranged in order of relative physical locations on chromosomae 19.13q.41; the neighbouring miR-371-3 cluster is also shown. ^bThe two MSC cell lines were used in comparison with the three iPSC lines derived. “+” and “-” indicate detectable and undetectable expression of the miRNA, respectively, in both cell lines; “+/-” indicates that one of the two MSC was positive and the other one was negative. n.d. not done
*p < 0.05, **p < 0.01

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