Skip to main content

Table 3 Common validated target genes shared between the C19MC-AAGUGC-miRNAs and the miR-302/-372 families

From: Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

AAGUGC-miRNA

Seed positiona

Target transcript

References

miR-302/-372

C19MC

miR-302c

miR-520e

I

NIK

[10, 15]

miR-373

miR-520c

I

MT1-MMP, mTOR, SIRT1

[14, 21]

miR-372, -373

miR-520c, -520e

I

RelA

[12]

miR-302b, -372, -373

miR-520c, -520e

I

TGFβR2

[9, 12]

miR-520b, -520e

I

CD46

[16]

miR-302c

miR-520c

I

MICA, MICB, ULBP2

[17]

miR-519a

I

RBL2

[13]

miR-512

IIa

  

miR-519d, -520g

IIb

SMAD7

[19, 20]

miR-520g, -520h

IIb

DAPK2

[18, 22]

miR-302d, -372

miR-520b, -519b-3p, -520a-3p

I

CDKN1A

[5, 6]

miR-519e

IIa

  

miR-519d, -520h

IIb

  
  1. aGroup I seed position is the canonical nts 2-7; IIa is nts 1-6 and IIb is other non-canonical position, as defined in Fig. 2a