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Table 2 The association between ALDH2 polymorphism and alcohol-related cancers

From: ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective

Cancer type Level of association with ALDH2 polymorphism Summary of current literature
Head and neck cancer Strong Most studies showed a synergistic interaction between ALDH2*2 allele and alcohol drinking to increase head and neck cancer risk [2629].
Esophageal cancer Strong Overall, literature provides strong evidence to support the synergistic interaction between ALDH2*2 allele and alcohol consumption to increase the risk of esophageal cancer [31].
Liver cancer Weak Overall, studies to date have consistently shown that ALDH2*2 does not independently contribute to liver cancer risk. Whether ALDH2*2 can modify the association between alcohol consumption and liver cancer risk requires further investigation [3241].
Breast cancer Weak Results from the only three studies published to date do not support a significant association between ALDH2*2 and breast cancer [4244].
Colorectal cancer Weak The role of ALDH2*2 in the development of colorectal cancer is inconclusive and all of the studies conducted to date have a small sample size that resulted in insufficient statistical power and lack of precision [32, 4547].