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Table 1 Concentration of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), noradrenaline (NA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in respective left (L) and right (R) brain structures (striatum and brainstem) in sham and 6-OHDA treated rats evaluated by HPLC detection ex vivo

From: Serotonergic system in hypoxic ventilatory response in unilateral rat model of Parkinson’s disease

Brain structure

Dopamine

Noradrenaline

DA

DOPAC

NA

MHPG

Sham

6-OHDA

Sham

6-OHDA

Sham

6-OHDA

Sham

6-OHDA

Striatum

Left

9132 ± 599

7737 ± 1301

3665 ± 210

4956 ± 818

17.04 ± 1.4

18.00 ± 2.0

23.60 ± 3.9

11.71 ± 1.9

Right

8314 ± 861

63.7 ± 72.2*

3662 ± 264

5.37 ± 6.2*

26.63 ± 8.6

16.27 ± 7.0

32.52 ± 8.8

13.43 ± 1.4

Brainstem

Left

40.20 ± 6.7

46.42 ± 5.2

29.51 ± 5.8

50.55 ± 3.9

623.81 ± 18.4

575.52 ± 15.4

1.76 ± 0.4

0.99 ± 0.2

Right

40.40 ± 4.5

29.81 ± 13.2

33.83 ± 3.4

27.89 ± 13.1

617.09 ± 20.1

573.21 ± 21.1

1.19 ± 0.3

1.02 ± 0.2

  1. Data are expressed as mean ± SEM (in pg/mg). Significantly different values are in bold. * P < 0.05, comparison between sham and 6-OHDA groups