Fig. 1

Combined effect of estradiol levels and polygenic risk score on the risk of ischemic stroke. The odds ratios (ORs) were adjusted for age, cigarette smoking/alcohol consumption, hypertension, diabetes mellitus, heart disease, and stroke family history. Estradiol levels were divided into high and low groups according to median log-transformed estradiol levels in female and male controls. The second quartile (Q2) of the polygenic risk score in controls was used as a cutoff point