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Table 2 Association between inflammatory genes and the risk of ischemic stroke

From: Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Gene SNP ID Allele risk/reference ORa (95% CI)
Per-allele p value Dominant model p value Recessive model p value
MCP-1 rs1024611 A/G 1.16(0.96–1.39) 0.1154b 1.23(0.93–1.63) 0.1492 1.19(0.87–1.64) 0.2753
rs3760396 C/G 0.93(0.69–1.27) 0.6585 1.02(0.73–1.43) 0.9120 0.29(0.09–1.26) 0.1420
CCR2 rs1799864 C/T 1.14(0.89–1.47) 0.3062 1.36(0.67–2.74) 0.3922 1.15(0.84–1.56) 0.3851
rs1799865 C/T 1.06(0.87–1.29) 0.5615 1.00(0.77–1.31) 0.9882 1.27(0.85–1.91) 0.1424b
E-selectin rs2076059 T/C 1.26(0.96–1.66) 0.0950 1.37(1.01–1.84) 0.0411b 0.73(0.26–2.08) 0.5605
rs10800469 A/G 1.02(0.86–1.22) 0.8060 0.97(0.74–1.28) 0.8266 1.11(0.85–1.50) 0.5074
rs3917412 A/G 1.00(0.82–1.21) 0.9769 0.92(0.71–1.19) 0.5150 1.28(0.84–1.94) 0.2553
rs5368 T/C 1.11(0.90–1.38) 0.3368 0.78(0.42–1.42) 0.4118 1.22(0.94–1.58) 0.1330b
  1. Abbreviations: OR odds ratio, CI confidence interval
  2. aORs were adjusted for age, body-mass index, cigarette smoking/alcohol consumption, hypertension, diabetes mellitus, heart disease, and stroke family history
  3. bIncluded in the polygenic risk score