Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Table 2 Association between inflammatory genes and the risk of ischemic stroke

Gene	SNP ID	Allele risk/reference	OR^a (95% CI)
Gene	SNP ID	Allele risk/reference	Per-allele	p value	Dominant model	p value	Recessive model	p value
MCP-1	rs1024611	A/G	1.16(0.96–1.39)	0.1154^b	1.23(0.93–1.63)	0.1492	1.19(0.87–1.64)	0.2753
MCP-1	rs3760396	C/G	0.93(0.69–1.27)	0.6585	1.02(0.73–1.43)	0.9120	0.29(0.09–1.26)	0.1420
CCR2	rs1799864	C/T	1.14(0.89–1.47)	0.3062	1.36(0.67–2.74)	0.3922	1.15(0.84–1.56)	0.3851
CCR2	rs1799865	C/T	1.06(0.87–1.29)	0.5615	1.00(0.77–1.31)	0.9882	1.27(0.85–1.91)	0.1424^b
E-selectin	rs2076059	T/C	1.26(0.96–1.66)	0.0950	1.37(1.01–1.84)	0.0411^b	0.73(0.26–2.08)	0.5605
	rs10800469	A/G	1.02(0.86–1.22)	0.8060	0.97(0.74–1.28)	0.8266	1.11(0.85–1.50)	0.5074
	rs3917412	A/G	1.00(0.82–1.21)	0.9769	0.92(0.71–1.19)	0.5150	1.28(0.84–1.94)	0.2553
	rs5368	T/C	1.11(0.90–1.38)	0.3368	0.78(0.42–1.42)	0.4118	1.22(0.94–1.58)	0.1330^b

Abbreviations: OR odds ratio, CI confidence interval
^aORs were adjusted for age, body-mass index, cigarette smoking/alcohol consumption, hypertension, diabetes mellitus, heart disease, and stroke family history
^bIncluded in the polygenic risk score

ISSN: 1423-0127