Fig. 1

Experimental groups, cell viability and glandular lesion features of the prostate. a Scheme of the experimental design of the different groups b and c PC3 and LNCaP viability after Nintedanib treatment. d acini with healthy glandular areas/without lesion (asterisk) and low grade PIN occurrence (arrow). e high grade PIN (arrow), acini with lumen occupied by epithelial projections (cribriform type - Cr). f Epithelial cell invasion through the stroma with membrane basal discontinuity (arrow), characterizing well-differentiated adenocarcinoma. g Glandular disorganization with acini structure loss, characterizing undifferentiated adenocarcinoma. Hematoxylin and Eosin, 400x, bar = 100 μm