Fig. 10

Body weight gain and photomicrography of the liver in TRAMP mice from control and treated groups. a Body weight gain of control and treated TRAMP animals. b TC12. c TN12. d TC22(8–12). e TN22 (8–12). Normal liver arrangement is noted. The typical hepatic histology with some hepatocytes with large nuclei, indicating polyploidy can be seen in the liver of 12-week-old mice (A and B). Only the presence of polyploid hepatocytes is more frequent in control mice (C) and treated mice (D) in 22 weeks of age. Hematoxylin and Eosin. 200x, bar = 200 μm