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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Nintedanib antiangiogenic inhibitor effectiveness in delaying adenocarcinoma progression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

Fig. 2

Frequency of the different lesion types and photomicrographs of the prostate ventral lobe. a Normal prostatic acini. b Low-grade PIN. c High-grade PIN and d Well-differentiated adenocarcinoma. Values expressed as average percentage. *p < 0.05 e atypical secretory epithelial cells in the prostate, highlighting cellular increase (1000x, bar = 20 μm). f T8 group – epithelial cell proliferation; low grade PIN foci (arrow); inset: 1000x, bar = 20 μm. g TC12 group – cellular proliferation with prostatic epithelium stratification, occupying acinus lumen, characterizing high grade PIN with cribriform feature acini (Cr); h TN12 group – epithelial atrophy and cellular proliferation scarcity (inset (1000x, bar = 20 μm)). i TC16 group – High grade PIN foci, cribriform feature acini (Cr and inset (1000x, bar = 20 μm)). j TN16 group – a slight decrease of cellular proliferation and epithelial atrophy (arrow). k TC22(8–12) group – cellular proliferation foci, characterizing well-differentiated adenocarcinoma (arrows); inset: 1000x, bar = 20 μm. l TN22(8–12) group and n TN22(12–16) group – Occasional cellular proliferation foci. m TC22(12–16) group – Cellular proliferation and infiltration in the stroma (inset), with well-differentiated adenocarcinoma foci (arrow). o accumulation of inflammatory cells and thickening of the collagen fiber layer (asterisk) (1000x, bar = 20 μm). p T8 group – normal distribution of fibrillar elements. q TC12 group – slight increase of fibrillar elements. r TN12 group – fibrillar stromal elements distributed regularly around the glandular acini. s TC16 group –a slight thickening of collagen fibers layer (arrow). t TN16 group – stroma without changes in the fibrillar and cellular elements. u TC22(8–12) and x TC22(12–16) groups – hyperplasia and hypertrophy of muscle cells, thickening of collagen fibers layer (U, arrow) and inflammatory cell accumulation (X, arrow) (inset (1000x, bar = 20 μm). v TN22(8–12) and z TN22(12–16) groups – occasional foci of inflammatory cells and layers of collagen fibers. Ep = epithelium; St = estroma; L = lumen; Cr = cribriform acinus, Col = collagen fibers; Smc = smooth muscle cells. Hematoxylin-Eosin and Masson Tricomic. (E to Z: 200x, bar = 200 μm. Insets: 1000x, bar = 20 μm)

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