KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment

Table 2 Features and epileptiform behaviours observed in the studied groups

Group	Weight (g)	Subgroups	Bursts	Behaviours	Death
CTL	254.99 ± 20.03	4-AP	1–3	facial, head and forelimb clonus, wild running and rearing	Not observed
		KB-R7943	0-2^b,c	clonic convulsions of head	Not observed
		4-AP + KB-R	0-4^b,c	clonic convulsions of head	Not observed
GMS	164.53 ± 10.70^a	4-AP	6-11^b	facial, head and forelimb clonus and GTCS	Observed in 1 animal
		KB-R7943	0-1^b,c	facial clonus	Not observed
		4-AP + KB-R	0-1^b,c	facial clonus	Not observed

^a p < 0.01 CTL vs. MSG animals, using Student’s t-test; ^b p < 0.05 all subgroups compared to CTL/4-AP, and ^c p < 0.05 all subgroups compared to MSG/4-AP, both using Mann–Whitney U test. Doses: 3 nmol of 4-AP and 62.5 nmol of KB-R7943 (also named KB-R)

ISSN: 1423-0127