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Table 1 Ion-dependence of [14C]L-citrulline uptake in TR-BBB cells

From: Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)

Substrate

Uptake of [14C]L-citrulline

(% of control)

Control

100 ± 1.9

Choline Chloride

83.3 ± 5.7

LiCl

116.2 ± 5.2

Sodium gluconate

103.9 ± 6.8

  1. [14C]L-Citrulline uptake by TR-BBB cells was performed at pH7.4 and 37 °C for 5 min in the presence or absence of sodium and/or chloride. Each value represents the mean ± S.E.M. (n = 3–4)