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Table 3 Effect of several transporter inhibitors on uptake of [14C]L-citrulline in TR-BBB cells

From: Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)

Substrate

Concentration

(mM)

Uptake of [14C]L-citrulline

(% of control)

Control

 

100 ± 1.3

BCH

2

25.3 ± 4.4***

20

28.1 ± 11.6***

Harmaline

2

61.0 ± 10.5**

Methylmaleimide

2

103.2 ± 10.1

Homoarginine

2

95.98 ± 13.8

MeAIB

2

99.8 ± 6.3

  1. [14C]L-Citrulline uptake by TR-BBB cells was performed at pH7.4 and 37 °C for 5 min in the presence or absence of 2–20 mM inhibitors. Each value represents the mean ± S.E.M. (n = 3–4). **p < 0.01, ***p < 0.001; significantly different from control
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Journal of Biomedical Science

ISSN: 1423-0127