Fig. 3

ALDH2*2 knock-in mice show lower level of ALDH2 activity in the kidney compared to wild type mice. Wild type and ALDH2*2 knock-in mice were treated with cisplatin, euthanized in two days and kidney tissues were collected. Cell homogenates were spun to isolate mitochondria (Figure 3) and ALDH2 activity was measured. Results represent mean ± SEMs (*p < 0.05 and **p < 0.05 vs. wild type (WT) control (t-test), and # p < 0.05 vs. PBS HET control (t-test))