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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

Fig. 5

Spinal cord transection injury and transplantation of OEC a: Scheme showing segments of thoracic spinal cord (T7 ~ T9; R: rostral; C: caudal). The location of GFP expressing OEC was depicted (EDF), b Complete transection injury (with a 5 mm gap) in thoracic spinal cord, c: Transplantation of fibrin glue-mixed OEC to the transection cavity, d-f GFP-expressing OEC in the transection cavity of spinal cord at 1 week post-transplantation. d Higher magnification of GFP (+) OEC. Bar = 150 μm in d, 50 μm in e&f. g-i GFP-expressing OEC in the spinal stumps of 3 week SCI rats at 4–5 mm rostral or caudal to the lesion epicenter. Bar = 50 μm. Adult OEC were prelabelled with GFP by adenovirus- mediated gene transfer before transplantation. Note: At one week post-transplanation, GFP (+) OEC were found in the transected cavity (in d) and in regions close to both spinal stumps (marked with star in e & f). At 3 weeks postgraft, GFP (+) OEC migrated to both stumps at 4–5 mm rotstral or caudal to the lesion epicenter. Grafted AdGFP-OEC could survive and express GFP persistently in the host spinal cord for at least 3 weeks

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