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Table 1 Results of animal behavior, neuronal tracing of WGA-HRP and 5-TH immunoreactivity at 12 weeks after injury and treatment

From: Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

Rats

WGA-HRP tracing

5-HT

Behavioral test (12 W)

Anterograde

Retrograde

 

BBB

CBS

Tx only

 1

-

 

-

0

80

 2

 

-

-

0

80.5

 3

-

 

-

0.5

77.5

 4

  

-

0.5

76

 

0%

0%

  

Tx + OEC Tp

 5

-

 

-

5

63

 6

 

-

-

2.5

65

 7

-

 

-

4.5

60

 8

  

+

3

64.5

 9

-

 

-

2

64.5

 10

-

 

-

3.5

63

 

0%

16.7%

  

Tx + AdPGIS-OEC Tp

 11

+ (T12)

 

+

7

44

 12

-

 

+

6

46.5

 13

-

 

-

4

59

 14

+ (T12)

 

+

6

46

 15

 

-

-

3

66

 

40%

60%

  
  1. A few 5HT (+) fibers were found in the distal stump, within 1 mm distal to the transected gap, in one Tx + OEC Tp and three Tx + AdPGIS-OEC Tp rats
  2. Anterograde tracing was conducted from motor cortex in experimental rats. WGA (+) fibers were found in the thoracic level 12 in two Tx + AdPGIS-OEC Tp rats. Whereas retrograde tracing was conducted from T12, no WGA (+) signals were found in the motor cortex of SCI rats (one rat per group)