Fig. 1
From: Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions
Mechanisms of DcR3.Fc-mediated immunomodulation. a DcR3 modulates the activation and differentiation of myeloid cells via HSPGs. DcR3.Fc triggers downstream signaling via syndecan-2 and CD44v3 on monocytes to influence monocyte differentiation into dendritic cells (DCs) and macrophages (MÏ•). DcR3-treated DC skews allogenic T cell differentiation into Th2 phenotype, while DcR3-treated MÏ• displays typical M2 markers, and is able to enhance tumor growth and tissue repairing. b DcR3 modulates B cell activation via a yet-identified ligand on B cells. DcR3.Fc suppresses TLR2 ligand (Pam3CSK4) and Staphylococcus aureus cowan (SAC) strain-induced B cell activation via binding non-HSPG ligand(s) on B cells