Fig. 2
From: Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions
Autocrine loop of DcR3-mediated immunomodulation. Endogenous DcR3 is induced in cancer cells or keratinocytes by various stimuli, including UV, sex hormone, viruses, and cytokines. Endogenous DcR3 enhances tumor migration, metastasis, growth, and resistance to chemotoxicity in tumor cells. DcR3 is also upregulated in psoriatic lesions and impairs keratinocyte differentiation. Aberrant expression of DcR3 and DcR3 variants are observed in rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and asthma