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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Fig. 1

a Chemical structure of PA-6 (drawn in Accelrys Draw 4.1). b Compound PA-6 docked into a homology model of KIR2.1. Three subunits are shown in side view; the fourth is removed for clarity. The location of mutations V93I (M1 helix) and D172N (M2 helix) are depicted in spheres representation. PA-6, bound to the cytoplasmic domain, is shown as cyan spheres. Nitrogen atoms are coloured blue, oxygen atoms are shown in red. Approximate membrane boundaries are indicated as black dotted lines. The figure was generated with Pymol

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Journal of Biomedical Science

ISSN: 1423-0127