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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Fig. 3

PA-6 dose dependently inhibits IK1 currents carried by homotypic wild-type (WT), V93I and D172N KIR2.1 channels in the whole cell mode. a Comparison of whole cell IV-curves obtained from HEK293 cells expressing WT (closed circles), V93I (open squares) or D172N (closed triangles) KIR2.1 channels. Currents were elicited by 1 s test pulses ranging between −120 and +30 mV, in 10 mV increments and correct for liquid junction potential. b Whole cell steady state current IV-curves from WT, V93I and D172N KIR2.1 channels expressed in HEK293 under control (closed circles), 1 μM PA-6 (open squares) and 3 μM PA-6 conditions. Voltage protocol as in panel a

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