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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Fig. 4

PA-6 application for 24 h increases WT, V93I and D172N KIR2.1 channel expression. a Dose-dependent (0-5 μM) effect of 24 h exposure to PA-6 on HEK293T cells transiently transfected with WT, V93I and D172N KIR2.1 channels. NT indicates non-transfected cells. Ponceau staining was used as loading control for quantification (b) Summarized quantification data from WT (n = 11 independent western blots), V93I (n = 11) and D172N (n = 13) are shown in mean ± s.e.m. *** P < 0.001 vs. control, ** P < 0.01 vs. control, #P = 0.09 vs. control

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