From: Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena
lncRNA | Status upon hypoxia | HIF involvement | HRE location | References |
---|---|---|---|---|
HIF-independent regulation | ||||
  ATG9B (noncoding isoform) | Up-regulated | HIF independent | N.D. | [52] |
HIF-mediated direct transcriptional regulation | ||||
  HOTAIR | Up-regulated | HIF-1α dependent | ACACG (−1118/−1115) | [53] |
  H19 | Up-regulated | HIF-1α dependent | ACGTG (−111/−107) | |
ACGTG (−398/−394) | ||||
ACGTG (−1434/−1430) | ||||
  UCA1 | Up-regulated | HIF-1α dependent | ACACG (−1515/−1511) | |
ACGTG (−53/−49) | ||||
  NUTF2P3–001 | Up-regulated | HIF-1α dependent | TGGGCGTGGTG (−2114/−2104) | [56] |
  EFNA3 | Up-regulated | HIF-1α dependent | ACGTG (−295/−299) | [57] |
  HINCUT-1 (uc.475) | Up-regulated | HIF-1α dependent | GCTCGCATGCGCGG (−527/−514) | [58] |
CACACGTGCGCG (−1233/−1222) | ||||
CACGTGCGC (−1232/−1224) | ||||
  ANRIL | Up-regulated | HIF-1α dependent | ACACG (−712/−708) | [59] |
  GAPLINC | Up-regulated | HIF-1α dependent | ACGTG (−320/−324) | |
CACGC (−578/−582) | ||||
  lincRNA-p21 | Up-regulated | HIF-1α dependent & preference | CGTGTACCAC (−797/−788) | [61] |
CGTGAGCCAC (+2603/+2612) | ||||
  aHIF | Up-regulated | HIF-1α and/or HIF-2α dependent | GCACG (−2045/−2049) | |
GCGTG (−2057/−2061) | ||||
  MALAT1 | Up-regulated | HIF-2α dependent & preference | CGCGCGTGCGCA (−59/−70) | |
  NEAT1 | Up-regulated | HIF-2α dependent & preference | Identified by ChIP-Seq | |
  lncRNA-SARCC | VHL-dependent | HIF-2α dependent | ACGTGCTGA (−3258/−3250) | [70] |
HIF-mediated indirect epigenetic regulation | ||||
  WT1-AS | Up-regulated | HIF-1 dependent (Indirect: DNA demethylation) | N.D. | [63] |
  lncRNA-LET | Down-regulated | HIF-1α dependent (Indirect: Histone deacetylation) | N.D. | |
Undetermined hypoxia-induced regulation | ||||
  LncHIFCAR (MIR31HG) | Up-regulated | HIF-1α dependent | N.D. | [64] |
  linc-ROR | Up-regulated | N.D. | N.D. | [49] |
  lncRNA-AK058003 | Up-regulated | N.D. | N.D. | [50] |
  NBR2 | Up-regulated | N.D. | N.D. | [65] |
  lncRNA-AK123072 | Up-regulated | N.D. | N.D. | [66] |
  PVT1 | Up-regulated | N.D. | N.D. | [67] |
  ENST00000480739 | Down-regulated | N.D. | N.D. | [69] |