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Table 1 List of hypoxia-responsive lncRNAs

From: Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena

lncRNA Status upon hypoxia HIF involvement HRE location References
HIF-independent regulation
ATG9B (noncoding isoform) Up-regulated HIF independent N.D. [52]
HIF-mediated direct transcriptional regulation
HOTAIR Up-regulated HIF-1α dependent ACACG (−1118/−1115) [53]
H19 Up-regulated HIF-1α dependent ACGTG (−111/−107) [54, 71, 72, 122]
ACGTG (−398/−394)
ACGTG (−1434/−1430)
UCA1 Up-regulated HIF-1α dependent ACACG (−1515/−1511) [55, 123]
ACGTG (−53/−49)
NUTF2P3–001 Up-regulated HIF-1α dependent TGGGCGTGGTG (−2114/−2104) [56]
EFNA3 Up-regulated HIF-1α dependent ACGTG (−295/−299) [57]
HINCUT-1 (uc.475) Up-regulated HIF-1α dependent GCTCGCATGCGCGG (−527/−514) [58]
CACACGTGCGCG (−1233/−1222)
CACGTGCGC (−1232/−1224)
ANRIL Up-regulated HIF-1α dependent ACACG (−712/−708) [59]
GAPLINC Up-regulated HIF-1α dependent ACGTG (−320/−324) [60, 90]
CACGC (−578/−582)
lincRNA-p21 Up-regulated HIF-1α dependent & preference CGTGTACCAC (−797/−788) [61]
CGTGAGCCAC (+2603/+2612)
aHIF Up-regulated HIF-1α and/or HIF-2α dependent GCACG (−2045/−2049) [62, 73, 85]
GCGTG (−2057/−2061)
MALAT1 Up-regulated HIF-2α dependent & preference CGCGCGTGCGCA (−59/−70) [51, 74, 99, 103, 124]
NEAT1 Up-regulated HIF-2α dependent & preference Identified by ChIP-Seq [51, 74, 104, 105]
lncRNA-SARCC VHL-dependent HIF-2α dependent ACGTGCTGA (−3258/−3250) [70]
HIF-mediated indirect epigenetic regulation
WT1-AS Up-regulated HIF-1 dependent
(Indirect: DNA demethylation)
N.D. [63]
lncRNA-LET Down-regulated HIF-1α dependent
(Indirect: Histone deacetylation)
N.D. [68, 80]
Undetermined hypoxia-induced regulation
LncHIFCAR (MIR31HG) Up-regulated HIF-1α dependent N.D. [64]
linc-ROR Up-regulated N.D. N.D. [49]
lncRNA-AK058003 Up-regulated N.D. N.D. [50]
NBR2 Up-regulated N.D. N.D. [65]
lncRNA-AK123072 Up-regulated N.D. N.D. [66]
PVT1 Up-regulated N.D. N.D. [67]
ENST00000480739 Down-regulated N.D. N.D. [69]
  1. Abbreviation: N.D. Not determined