Fig. 3
The A2AR and baicalin reduced pulmonary arterial remodeling in the hypoxia-induced PAH mouse model. Effects of baicalin (+Bai, 60 mg/kg/day) and CGS21680 (+CGS, 0.25 mg/kg/day) on the WT/TT(%) (a; n = 8), WA/TA(%) (b; n = 8) reversal in WT and A2AR−/− mice. Representative images showing hypoxia-induced remodeling in the pulmonary arteries of mice in the WT and A2AR−/− groups (c) (×400; scale bars indicate 50 μm), Data are presented as the mean ± SD. #Value significantly greater than the corresponding value in saline-treated normoxic mice (# P < 0.05, ## P < 0.01). *Value significantly less than the corresponding value in mice subjected to 4 weeks of hypoxia (*P < 0.05, **P < 0.01). +Value significantly greater than the corresponding value in WT saline-treated miceand WT baicalin-treated mice (+ P < 0.05). WTH, wild-type hypoxic; A2AR−/−H, A2AR−/− hypoxic; s, saline-treated