Fig. 4

Effects of the A_2AR and baicalin on P_aO₂ and pH in the hypoxia-induced PAH mouse model. Effects of baicalin (+Bai, 60 mg/kg/day) and CGS21680 (+CGS, 0.25 mg/kg/day) on P_aO₂ (a; n = 10) and pH (b; n = 10) in WT and A_2AR^−/− mice. Data are presented as the mean ± SD. ^#Value significantly less than the corresponding value in saline-treated normoxic mice (^# P < 0.05, ^## P < 0.01). *Value significantly greater than the corresponding value in mice subjected to 4 weeks of hypoxia (*P < 0.05, **P < 0.01). ⁺Value significantly different between WT and A_2AR^−/− mice (⁺ P < 0.05, ⁺⁺ P < 0.01). WTH, wild-type hypoxic; A_2AR^−/−H, A_2AR^−/− hypoxic; s, saline-treated