Fig. 3
From: Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies
Immunolocalization of caveolin-3 wild type and caveolin-3 V82I mutant. BHK cells were transiently transfected with plasmids expressing caveolin-3 wild type (Cav-3 WT) (a) or caveolin-3 V82I mutant (Cav-3 V82I) (b) and immunostained with antibodies against caveolin-3 followed by Alexa Fluor 488-conjugated secondary antibodies. Cav-3 V82I was retained intracellularly and not properly targeted to the plasma membrane as with Cav-3 WT (arrowheads). Vesicle-like structures stained with caveolin-3 antibodies were also observed, especially for Cav-3 V82I (arrows). Scale bar: 10 μm. The figure has been completely adopted from [22]