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Table 3 Cardiovascular analysis of line Kctd1 I27N by echocardiography

From: Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Parameter Heterozygous mutant males Wild-type males Heterozygous mutant females Wild-type females Genotype:
P-value
IVSs (mm) 0.55 ± 0.03 0.55 ± 0.02 0.55 ± 0.02 0.54 ± 0.02  
IVSd (mm) 0.54 ± 0.02 0.54 ± 0.02 0.55 ± 0.02 0.54 ± 0.02 0.04
LVPWs (mm) 0.54 ± 0.03 0.54 ± 0.02 0.54 ± 0.02 0.54 ± 0.02  
LVPWd (mm) 0.54 ± 0.03 0.56 ± 0.02 0.54 ± 0.01 0.55 ± 0.02 0.03
LVIDs (mm) 1.39 ± 0.49 1.44 ± 0.60 1.53 ± 0.56 1.69 ± 0.46  
LVIDd (mm) 2.87 ± 0.43 2.87 ± 0.57 2.85 ± 0.47 2.98 ± 0.32
Heart rate (bpm) 579 ± 114 530 ± 150 474 ± 167 453 ± 122
Respiration rate (1/min) 264 ± 36 250 ± 29 224 ± 50 238 ± 52
Body weight (g) 31.3 ± 1.4 32.3 ± 1.9 26.8 ± 1.6 27.1 ± 2.1
  1. 15-week-old mice were tested. Number per genotype and sex: n = 14–15. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05
  2. IVSs interventricular septum in systole, IVSd interventricular septum in diastole, LVPWs left ventricular posterior wall in systole, LVPWd left ventricular posterior wall in diastole, LVIDs left ventricular internal dimension in systole, LVIDd left ventricular internal dimension in diastole