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Table 4 Clinical chemical analysis of line Kctd1 I27N

From: Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Parameter Heterozygous mutant males Wild-type males Heterozygous mutant females Wild-type females Genotype: P-value
Na (mmol/l) 157 ± 2 156 ± 2 156 ± 3 156 ± 2  
K (mmol/l) 5.1 ± 0.3 4.6 ± 0.2 4.4 ± 0.2 4.1 ± 0.2 < 0.001
Ca (mmol/l) 2.5 ± 0.1 2.5 ± 0.1 2.6 ± 0.1 2.5 ± 0.1 < 0.001
Cl (mmol/l) 113.5 ± 1.7 114.8 ± 1.7 113.9 ± 1.5 117.1 ± 1.4 < 0.001
Pi (mmol/l) 2.2 ± 0.2 2.2 ± 0.3 2.1 ± 0.3 2.1 ± 0.3  
Total protein (g/l) 51.3 ± 2.4 51.6 ± 1.9 50.7 ± 1.9 48.7 ± 1.6
Creatinine (μmol/l) 9.4 ± 1.5 7.8 ± 1.2 10.6 ± 0.7 9.5 ± 1.2 < 0.001
Urea (mmol/l) 18.2 ± 1.5 10.8 ± 0.8 16.9 ± 1.4 10.1 ± 1.1 < 0.001
Cholesterol (mmol/l) 4.1 ± 0.4 4.2 ± 0.4 3.0 ± 0.3 2.8 ± 0.3  
Triglycerides (mmol/l) 4.1 ± 0.5 4.2 ± 1.2 3.4 ± 0.8 3.4 ± 1.0
ALT (U/l) 37 ± 4 39 ± 9 32 ± 3 32 ± 3
AST (U/l) 50 ± 6 54 ± 17 51 ± 7 51 ± 7
AP (U/l) 90 ± 5 97 ± 8 132 ± 12 135 ± 8 0.04
α-Amylase (U/l) 776 ± 162 652 ± 54. 695 ± 91 534 ± 39 < 0.001
Glucose (mmol/l) 10.5 ± 2.0 9.2 ± 1.6 10.2 ± 1.5 9.8 ± 1.2 P > 0.05 (0.06)
Albumin (g/l) 28.7 ± 1.3 28.3 ± 1.3 30.8 ± 1.3 29.4 ± 1 0.02
  1. 17-week-old mice were tested. Number per genotype and sex: n = 11–14. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05
  2. Creatinine plasma creatinine analyzed by the enzymatic method, ALT alanine aminotransferase, AST aspartate aminotransferase, AP alkaline phosphatase