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Table 5 Hematological analysis of line Kctd1 I27N

From: Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Parameter Heterozygous mutant males Wild-type males Heterozygous mutant females Wild-type males Genotype:
P-value
WBC (103/μl) 10.6 ± 1.5 10.6 ± 2.0 10.9 ± 1.8 9.6 ± 1.2  
RBC (106/μl) 9.5 ± 0.4 10.2 ± 0.3 9.8 ± 0.4 9.8 ± 0.3 0.001
PLT (103/μl) 989 ± 158 1051 ± 72 982 ± 63 1002 ± 60  
HGB (g/dl) 15.4 ± 0.6 16.5 ± 0.5 15.7 ± 0.6 16.3 ± 0.8 < 0.001
HCT (%) 44.8 ± 1.7 48.1 ± 1.3 46.0 ± 1.7 46.6 ± 1.3 < 0.001
MCV (fl) 47.1 ± 0.6 47.3 ± 0.5 47.1 ± 0.5 47.6 ± 0.6 0.005
MCH (pg) 16.1 ± 0.5 16.2 ± 0.3 16.1 ± 0.3 16.6 ± 0.5 0.005
MCHC (g/dl) 34.3 ± 1.0 34.2 ± 0.5 34.3 ± 0.7 34.9 ± 1.0  
  1. 17-week-old mice were tested. Number per genotype and sex: n = 14–15. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05
  2. WBC white blood cell count, RBC red blood cell count, PLT platelet count, HGB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration