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Table 7 Analysis of energy metabolism in line Kctd1 I27N

From: Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Test Parameter Heterozygous mutant males Wild-type males Heterozygous mutant females Wild-type females Geno-type:
P-value
Indirect calori-metry Body weight (g) 28.3 ± 1.2 29.2 ± 1.7 24.1 ± 1.6 24.0 ± 2.7  
  Food intake (g) 0.9 ± 0.5 1.2 ± 0.6 1.4 ± 0.8 1.7 ± 0.7
Average VO2 consumption (ml/h) 86 ± 6 88 ± 8 82 ± 10 82 ± 13
Average RER (VCO2/VO2) 0.79 ± 0.03 0.81 ± 0.02 0.81 ± 0.04 0.83 ± 0.04 0.03
Average distance (cm in 20 min) 2777 ± 810 2386 ± 755 4467 ± 5870 3681 ± 3512  
TD-NMR Body weight (g) 27.4 ± 1.2 28.4 ± 1.7 23.8 ± 1.4 24.1 ± 1.8
  Fat mass (g) 5.7 ± 0.7 6.2 ± 0.9 5.5 ± 0.7 5.6 ± 0.9
Lean mass (g) 17.7 ± 0.6 18.1 ± 0.9 14.7 ± 0.8 14.9 ± 0.8
  1. Analysis was done on 13-week-old mice under ad libitum conditions. n = 14–15 per genotype and sex. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05
  2. RER respiratory exchange ratio, TD-NMR time domain nuclear magnetic resonance