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Table 7 Analysis of energy metabolism in line Kctd1 I27N

From: Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Test

Parameter

Heterozygous mutant males

Wild-type males

Heterozygous mutant females

Wild-type females

Geno-type:

P-value

Indirect calori-metry

Body weight (g)

28.3 ± 1.2

29.2 ± 1.7

24.1 ± 1.6

24.0 ± 2.7

 
 

Food intake (g)

0.9 ± 0.5

1.2 ± 0.6

1.4 ± 0.8

1.7 ± 0.7

Average VO2 consumption (ml/h)

86 ± 6

88 ± 8

82 ± 10

82 ± 13

Average RER (VCO2/VO2)

0.79 ± 0.03

0.81 ± 0.02

0.81 ± 0.04

0.83 ± 0.04

0.03

Average distance (cm in 20 min)

2777 ± 810

2386 ± 755

4467 ± 5870

3681 ± 3512

 

TD-NMR

Body weight (g)

27.4 ± 1.2

28.4 ± 1.7

23.8 ± 1.4

24.1 ± 1.8

 

Fat mass (g)

5.7 ± 0.7

6.2 ± 0.9

5.5 ± 0.7

5.6 ± 0.9

Lean mass (g)

17.7 ± 0.6

18.1 ± 0.9

14.7 ± 0.8

14.9 ± 0.8

  1. Analysis was done on 13-week-old mice under ad libitum conditions. n = 14–15 per genotype and sex. Data are presented as mean ± standard deviation. Significance vs. wild-type controls: Exact P values are indicated for P < 0.05
  2. RER respiratory exchange ratio, TD-NMR time domain nuclear magnetic resonance