Fig. 2
Severer cardiac remodeling in hearts of AC6ΔN/ΔN and AC6−/− mice. Mice were daily injected with ISO (10 mg/kg/day) or saline for 5 days. Hearts were carefully removed, weighted, and used to prepare heart sections, which were then subjected to collagen stain and TUNEL assay. a Representative pictures of collagen stain. Scale bar, 1 mm. b Quantitation of heart weight, and fibrosis ratio. AC6+/+/saline, N = 4; AC6ΔN/ΔN/saline, N = 3; AC6−/−/saline, N = 3; AC6+/+/ISO, N = 6; AC6ΔN/ΔN/ISO, N = 4; AC6−/−/ISO, N = 4. * P < 0.05, vs. AC6+/+. # P < 0.05, vs. the saline group. c Representative pictures of TUNEL assay. Scale bar, 50 μm. d Quantitation of TUNEL-positive cells. N = 3 in each group. * P < 0.05, vs. AC6+/+. # P < 0.05, vs. the saline group