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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: FTO associations with obesity and telomere length

Fig. 1

FTO gene interacts with telomere length and obesity. FTO interacts with uncoupling protein 2 (UCP2), AMP-activated protein kinase (AMPK), retinoblastoma-like 2 protein (RBL2), Iroquois homeobox protein 3 (IRX3), cut like homeobox 1 (CUX1) and mammalian target of rapamycin complex 1 (mTORC1). These interactions are important for dietary behavior regulation and cellular nutrient sensing. Additionally, the hypothesis is presented that the FTO genotype may influence telomere regulation. Bold arrow means there is published evidence; dotted arrow means there is rational speculation but without published evidence

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