Fig. 3

TRIM28 is highly expressed in many types of tumors (The Human Protein Atlas data). Immunohistochemistry was performed with rabbit polyclonal antibody HPA064033 (Sigma Aldrich). Strong nuclear staining is observed in almost all types of cancers presented in The Human Protein Atlas database. Only lymphoma and liver and kidney tumors present medium intensity for TRIM28 staining. Normal tissues showed moderate to strong nuclear positivity with HPA064033 antibody as presented at the bottom, however in most cancer types the presence of TRIM28 in cancer cell nuclei is more pronounced than in adjacent normal tissues