Fig. 6

TRIM28 together with CBF-A bound to FTS-1 sequence forms a proximal activator of transcription in epithelial-mesenchymal transition, enhancing the expression of EMT transcriptome. CBF-A/TRIM28 complex binds to FTS-1 (fibroblast transcription site-1) response elements that exist in the promoters of genes modulating EMT transcriptome (including promoters of TWIST1, SNAI1, HMGA2, LEF1, ETS1, etc.) leading to acquisition of mesenchymal phenotype and loss of epithelial-related gene expression. Formation of CBF-A/TRIM28/FTS-1 is sufficient for the induction of epithelial-mesenchymal transition